Analysis of the algorithm: From rankings to backup genes.

Ranking section

For each of the affected genes present in the list, a ranking with the score and percentile of every possible gene was obtained. Once this was done, the position for every known backup gene was obtained and the statistical descriptor of all the values calculated.

Table 1. Backup position values for every kernel and net before integration.

Net Kernel Elements Min Max Average Standard_Deviation
biological_process ct 70 0.0 0.944 0.111 0.225
biological_process el 70 0.0 0.941 0.133 0.254
biological_process ka 70 0.001 1.0 0.477 0.494
biological_process node2vec 70 0.0 0.655 0.072 0.144
biological_process rf 70 0.0 0.945 0.112 0.225
cellular_component ct 4 0.001 0.233 0.137 0.1
cellular_component el 4 0.001 1.0 0.75 0.432
cellular_component ka 4 0.001 1.0 0.75 0.432
cellular_component node2vec 4 0.001 0.561 0.349 0.211
cellular_component rf 4 0.001 1.0 0.75 0.432
disease ct 24 0.002 0.981 0.264 0.37
disease el 24 0.002 0.98 0.227 0.343
disease ka 24 0.005 1.0 0.395 0.469
disease node2vec 24 0.003 0.749 0.146 0.229
disease rf 24 0.002 0.979 0.262 0.368
genetic_interaction_weighted ct 73 0.0 0.955 0.276 0.258
genetic_interaction_weighted el 73 0.003 1.0 0.339 0.32
genetic_interaction_weighted ka 73 0.025 1.0 0.781 0.397
genetic_interaction_weighted rf 73 0.0 1.0 0.33 0.322
molecular_function ct 7 0.0 1.0 0.222 0.34
molecular_function el 7 0.0 1.0 0.286 0.452
molecular_function ka 7 0.0 1.0 0.286 0.451
molecular_function node2vec 7 0.0 0.058 0.016 0.025
molecular_function rf 7 0.0 1.0 0.286 0.452
pathway ct 30 0.001 0.994 0.074 0.179
pathway el 30 0.001 0.207 0.041 0.052
pathway ka 30 0.001 1.0 0.381 0.471
pathway node2vec 30 0.0 0.734 0.143 0.191
pathway rf 30 0.001 0.197 0.038 0.048
phenotype ct 23 0.0 0.917 0.184 0.276
phenotype el 23 0.0 1.0 0.228 0.345
phenotype ka 23 0.001 1.0 0.567 0.494
phenotype node2vec 23 0.001 0.833 0.221 0.275
phenotype rf 23 0.0 1.0 0.225 0.339
protein_interaction ct 73 0.003 0.193 0.03 0.029
protein_interaction el 73 0.002 0.412 0.084 0.093
protein_interaction ka 73 0.015 1.0 0.117 0.187
protein_interaction rf 73 0.003 0.193 0.03 0.029

Table 2. Backup position values for every kernel after integration

Integration Kernel Elements Min Max Average Standard_Deviation
integration_mean_by_presence ct 73 0.0 0.812 0.073 0.147
integration_mean_by_presence el 73 0.0 0.836 0.041 0.116
integration_mean_by_presence ka 73 0.0 1.0 0.037 0.121
integration_mean_by_presence node2vec 73 0.0 0.866 0.057 0.139
integration_mean_by_presence rf 73 0.0 0.343 0.023 0.054
mean ct 73 0.0 0.807 0.079 0.155
mean el 73 0.0 0.701 0.038 0.103
mean ka 73 0.0 1.0 0.042 0.125
mean node2vec 73 0.0 0.839 0.07 0.134
mean rf 73 0.0 0.362 0.029 0.065

Backup Pairs Coverage By Layer

CDF plots of non integrated kernels

CDF plots of integrated kernels